منابع مشابه
Cadmium-induced osteomalacia.
The detailed study of a battery plate maker, who had worked with cadmium for 36 years, showed that proteinuria, typical of renal tubular dysfunction, had been observed for 25 years and during the last 12 years of his life the patient had suffered increasing disability from gross bone disease. Several bone biopsies and detailed metabolic studies showed typical severe osteomalacia, which responde...
متن کاملTumor-induced osteomalacia.
Tumor-induced osteomalacia (TIO) is a rare paraneoplastic form of renal phosphate wasting that results in severe hypophosphatemia, a defect in vitamin D metabolism, and osteomalacia. This debilitating disorder is illustrated by the clinical presentation of a 55-year-old woman with progressive fatigue, weakness, and muscle and bone pain with fractures. After a protracted clinical course and exte...
متن کاملTumor-induced osteomalacia
Tumor-induced osteomalacia (TIO) is a rare paraneoplastic syndrome clinically characterized by bone pain, fractures and muscle weakness. It is caused by tumoral overproduction of fibroblast growth factor 23 (FGF23) that acts primarily at the proximal renal tubule, decreasing phosphate reabsorption and 1α-hydroxylation of 25 hydroxyvitamin D, thus producing hypophosphatemia and osteomalacia. Les...
متن کاملTenofovir-induced osteomalacia.
We present an HIV-infected woman in whom antiretroviral treatment with tenofovir disoproxil fumarate (TDF) induced severe skeletal pain, synovial effusions and multiple fractures secondary to a Fanconi syndrome with hypophosphatemia and osteomalacia. TDF interferes with the replication of mitochondrial DNA in the proximal tubules of the kidney, which can explain the delayed onset of this form o...
متن کاملCarbamazepine induced osteomalacia: letter to the editor.
A 45 year-old woman with epilepsy who was treated with Carbamazepine (CBZ) 600 mg/daily for six years was seen at the neurology outpatient clinic with the complaints of back pain, weakness, fatigue, dizziness and recurrence of seizures during the last 2 months while she had been seizure free during the previous 4 years. She had been receiving no other medications. Detailed dietary and environme...
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ژورنال
عنوان ژورنال: Occupational and Environmental Medicine
سال: 1980
ISSN: 1351-0711
DOI: 10.1136/oem.37.3.278